Go to this link for the list of upcoming discussion leaders and links to papers.
For the past few weeks I have been working with my friend and collaborator Maxime at the ILL in Grenoble, France. We’ve been working on a paper about the effects of fluctuations on proteins. It’s been really fun being the odd-one-out experimentalist amidst this group of dyed in the wool theorists.
Back in the lab, Dileep and Gabe are making enormous progress on the AFM. After just a few weeks of working in the lab it seems that they don’t need me at all!
Maxime Clusel sent me a link to this paper, “Elasticity of Globular Proteins Measured from the ac Susceptibility,” by Y Wang and G Zocchi. It details a beautiful experiment in which they measure the linear visco-elastic response of glubular proteins and short DNA molecules. They use the molecules to tether electrically charged gold nanoparticles to a surface and then excite the molecules by applying an electric potential and inducing movement of the nanoparticles. The resulting change in particle-surface distance (i.e. the amount that the molecule has stretched) is measured by evanescent wave scattering, which ends up with a resolution on the average extension of many molecules of ~ 0.1 Å! Incredible!